Ubiquilin overexpression reduces GFP-polyalanine-induced protein aggregates and toxicity
نویسندگان
چکیده
منابع مشابه
Suppression of polyglutamine-induced toxicity in cell and animal models of Huntington's disease by ubiquilin.
Expanded polyglutamine (polyQ) tracts are associated with the induction of protein aggregation and cause cytotoxicity in nine different neurodegenerative disorders. Here, we report that ubiquilin suppresses polyQ-induced protein aggregation and toxicity in cells and in an animal model of Huntington's disease. Overexpression of ubiquilin in HeLa cells and primary neurons reduced aggregation of p...
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ژورنال
عنوان ژورنال: Experimental Cell Research
سال: 2007
ISSN: 0014-4827
DOI: 10.1016/j.yexcr.2007.04.006